Solcoderm for papillomas: instructions, effect on HPV and analogues

The papillomavirus these days is spreading across the planet at a tremendous pace, leaving almost no chance for any of us to go unnoticed. The infection is insidious, as it can enter the body through an imperceptible microcrack in the skin and hide for a long period of time, sometimes this period stretches for several years. While the disease is in a calm state, it is not dangerous, but as soon as a person begins to notice growths of different diameters on the skin and mucous membranes, then it is time to go for examination to a dermatologist and to the pharmacy to get Solcoderm solution for papillomas.

Briefly about the drug

• Solcoderm is a medicinal product. Sold in many pharmacies with a doctor's prescription.
• The effect of the drug is local necrotizing. That is, it causes necrosis of the skin that is lubricated with it.
• Price 450 – 550 rubles per ampoule. One ampoule is enough for 5-7 warts.
• The treatment can be carried out at home. But the first treatment should be carried out under the supervision of a dermatologist.
• Can be used by pregnant women, BUT only on the skin.
• Solcoderm ointment: I have never seen such a drug, and it is impossible to imagine it. After all, acids are a liquid, not an ointment.

Results of using Solcoseryl after removal of papillomas

The photo shows the results of using Solcoseryl ointment after removing papillomas

According to the instructions for Solcoseryl ointment, treatment with this drug should not exceed 2-3 weeks. It is during this period that the effect of using the product is expected to occur, which manifests itself in the form of complete epidermization of the wound, that is, its healing.

At the same time, the formation of scars at the junction of tissues also qualifies as a positive effect from the use of the product. For their resorption, it is recommended to continue treatment with the product.

According to reviews of the use of Solcoseryl, this drug is considered highly effective.

Instructions for treating papillomas, condylomas and warts with solcoderm

1) If the wart is large with a large ridge around it, then the ridge must be carefully cut off with nail scissors.

2) Treat the skin with alcohol.

3) We buy a simple baby cream for 30 rubles at the Rospechat kiosk. Lubricate the skin around the papilloma well with cream.

4) Open the ampoule with Solcoderm.

5) Take the applicator. This is a plastic stick with a sharp end on one side and a blunt end on the other. If the wart is large, we use a blunt end. If it's small, it's spicy.

6) Dip the stick into the solcoderm solution. Apply a drop of solcoderm to the papilloma or condyloma.

7) If the papilloma is large and the drug solution is not enough to cover its entire surface, then take another drop and apply it to the wart. Using a blunt end, spread a drop of solution over the surface of the wart.

If you have a conglomerate of warts that have grown together, they can be treated with a glass capillary. You lower the capillary into an ampoule with a solution of solcoderm, it is drawn into the capillary itself. Take it and apply the solution to the warts gradually.

9) Do not apply many drops of solution at once. If it spreads around, it may cause skin burns. And in this case, the previous treatment of the skin with cream will be very useful.

10) The skin of papilloma or condyloma under the influence of solcoderm should first turn white and then become pale yellow-gray. If this color is achieved, no further processing is necessary.

If there are a lot of warts, then no more than 4-5 medium or 2-3 large warts can be treated at a time. Repeated treatment is possible only after 1-2 weeks.

What's next?

1) The next day, the treatment area becomes covered with a brown crust, like an ordinary wound.

2) After a few days the crust will begin to come off.

3) In a week the crust will disappear completely.

Indications for use and side effects

The drug is indicated for patients who require destruction of the following types of benign tumors on the surface of the skin:

• condylomas acuminata;
• papillomas and warts, the growth of which was caused by HPV.

As a result of treatment with Solcoderm, local negative reactions may develop:

• burning;
• formation of a white ischemic ring around the treated growth;
• the appearance of scar tissue;
• change in pigmentation;
• temporary redness.

Analogs

Solcoderm is a cauterizing drug. This means it has analogues:

• duofilm. The action is milder than that of Solcoderm. Read more about the duofilm.
• Collomak. Also the effect on the skin is softer. See detailed instructions.
• super celandine – harsh action due to strong alkalis (detailed instructions),
• verrucacid (or feresol). This is phenol + metacresol, the effect is average (more about the drug),
• lapis This is silver nitrate, it acts gently, but it takes a long time to smear. (more about lapis pencil),
• condilin (detailed instructions for condilin),
• solkovagin (read more about solkovagin) and a number of others.

If you choose by price, then the cheapest drug is super celandine. But you have to be very careful with it so as not to burn the skin.

special instructions

Solcoderm should not be used on inflamed areas of the skin.

Special care is required when treating benign skin tumors with Solcoderm that have previously been treated with other drugs or other methods.

After a biopsy of the affected skin area, it is recommended to wait 8-10 days before starting treatment with Solcoderm solution.

When treating affected areas of the skin located next to the mucous membranes, incl. near the eyes, special precautions should be taken.

If Solcoderm solution accidentally comes into contact with healthy skin, it should be immediately removed using a cotton swab moistened with water. If Solcoderm solution accidentally gets into the eye, it is necessary to immediately rinse the eye with a large amount of water or with a weak alkaline solution (1% sodium bicarbonate solution). Drops of Solcoderm solution that get on furniture or clothing must be washed off with water, since Solcoderm can destroy the materials from which they are made.

If pain occurs during application of the drug, treatment should be interrupted immediately.

If severe local irritation and severe itching occur in areas of the skin adjacent to the site of application of the drug, it is recommended to use a cream containing GCS or an ointment that has an anesthetic effect.

Until complete healing of the lesion treated with Solcoderm is achieved (approximately 2-4 months after therapy), exposure to direct sunlight and ultraviolet radiation should be avoided.

For each therapeutic procedure, it is necessary to use a new ampoule, because after opening the ampoule, the Solcoderm solution is chemically unstable. The opened ampoule should be stored strictly vertically by securing it in a special slot in the contour packaging for ampoules.

Before discarding the used ampoule, the remaining solution should be washed off in running water. The empty ampoule can be thrown into a waste container.

Use in pediatrics

There are no restrictions on the use of Solcoderm in children over 5 years of age.

Carefully!

Solcoderm is an aggressive solution. It can cause irreversible acid burns to the skin or mucous membranes. To prevent this from happening, remember:

1) Do not apply it to healthy skin.

2) You cannot apply it at home to the genitals and anal area.

3) Do not apply it to the oral mucosa.

4) It should not be applied to children at home.

5) You can’t apply it to your face.

Attention:

1) You should absolutely not apply it to moles and pimples.

2) If a burn does occur to healthy skin, or mucous membranes, or eyes, IMMEDIATELY (. ) rinse the area with plenty of plain tap water. And then contact a surgeon.

Reviews of Solcoderm from doctors and patients are good. As a doctor, I can only remind you once again that it is advisable to have the first treatment done by your dermatologist. You can see everything with your own eyes and you can repeat it at home.

I also recommend reading these materials:

Attention: if the doctor did not answer your question, then the answer is already on the pages of the site. Use the search on the site.

There are many ways to help get rid of warts. Some of them are quite expensive and complex; they are used only in outpatient settings. Others are based on the use of dubious drugs and conspiracies. It is not recommended for anyone to try such experiments over their health.

The easiest and most proven way to get rid of the problem is to find a suitable remedy for warts at the pharmacy. After all, with the help of a medication, you can easily remove the anomaly at home.

The choice of medications for skin growths in pharmacies is so wide that a person with any financial means can choose what they need. The main thing is to get a preliminary consultation with a dermatologist and go to the pharmacist with a list of acceptable medications.

How effective is the drug "Solcoderm" for condylomas?

Reviews about the drug are positive. The action of the acid leads to the death of modified cells and the destruction of the virus in them. In order to understand how acid directly affects the papilloma virus, consider the effect of the pathogen itself on skin cells.

The virus is aimed at modifying skin cells. The HPV gene is introduced into the nucleus of the epithelial cell, where information is read from the pathological genes of the virus. After this, the reprogrammed cells begin to reproduce the virus protein, which affects tissue changes. Thus, pathogenic epithelial cells grow with quantitative multiplication of the virus in the body.

The acids contained in the Solcoderm preparation lead to the coagulation of the protein shell of the virus and the death of the pathogen itself. Condylomas are growths of epithelial cells that contain protein, but not its natural protein, but read from the HPV gene. Genital warts, like other types of manifestations of the action of a pathogen in the body, cannot resist an explosive mixture of a number of acids. They become necrotic, then rejected by healthy tissue and fall off.

Is it always possible to treat warts with pharmaceuticals?

The appearance of skin growths is not a reason to panic. Most of them do not require quick and mandatory removal. However, in some cases, a wart can be very unsightly aesthetically or interfere with daily activities.

Drug treatment of warts is not always justified:

Warts on the face must be removed carefully

• It is better not to touch some growths on the skin at first, but simply observe;
• Damaged and rapidly growing warts can only be removed in a clinic.

Pharmaceutical products for warts on the face are selected very carefully. Too aggressive compositions can severely burn delicate skin. In this case, the epidermis must be immediately washed and the anti-burn drug Solcoseryl used.

Dermatologists do not approve of the removal of flat warts that are present on the hands. They occur in children and adolescents, frightening parents when they appear at such an early age. And although it is not problematic to buy a remedy for warts on your hands at the pharmacy, doctors advise you to wait. As you grow older, this anomaly will disappear without medical intervention.

You cannot choose pharmaceutical remedies for warts on your own. A person who does not have a medical education may mistake another skin pathology for a wart.

If the growth is still caused by papillomavirus, and its removal is advisable, then only a doctor can choose the best medicine. He will take into account the type of skin formation, size, condition and individual characteristics of the patient.

Solcoderm: reviews

Solcoderm has many positive reviews on thematic forums (but it is better not to use it for children). It is possible to remove skin tumors in children using this drug if the child has reached 5 years of age.

“ For a long time I was bothered by a wart on the inside of my nostril. She did not cause any discomfort, but I still felt her presence. A dermatologist advised me to try the cauterizing agent Solcoderm. He did everything in his office - the tumor dried up after cauterization, and fell off after a few days. There are no scars left ." Elena, 46 years old.

“ Only the Solcoderm solution helped me in removing several plantar warts that had been tormenting me for quite some time. If I walked for a long time, the growths became inflamed, which was extremely uncomfortable and painful. I had to treat it with Solcoderm several times, but I’m happy with the result - it’s as if nothing had happened .” Oleg, 29 years old.

In this video, starting from the 4th minute, an experienced dermatovenerologist reveals all the secrets of using Solcoderm for warts, papillomas and other formations on the skin:

Solutions

Many effective wart treatments come in liquid form. This solution is easy to apply and quickly absorbed.

Liquid preparations for removing warts can have a cauterizing or softening effect. In the first case, the tissues become necrotic, dry out and fall off entirely; in the second, they separate layer by layer.

Iodine is effective in fighting warts

The following drugs have proven themselves to be effective:

• Feresol;
• Verrucacid;
• Solcoderm;
• Collomak;
• Iodine;
• Hydrogen peroxide;
• Zelenka.

Only a doctor can determine whether it is possible to cauterize a wart or whether it is better to soften it. The patient must follow all the specialist’s recommendations and carry out the treatment only according to the instructions.

Feresol

Any cauterizing solution must be used extremely carefully. The drug for warts Feresol is no exception. The bottle comes with special applicators. They help to apply the mummifying composition pointwise, avoiding contact with healthy epidermal tissue.

When planning to use Feresol for warts, you need to take into account some features of its use:

• Minor anomalies are processed once;
• Medium and large - up to four times;
• To remove plantar formations, it may take about ten repeated applications of the product.

If the problem area is the genitals, then you should not carry out treatment yourself.

Feresol is a cauterizing solution

If the wart remover Feresol needs to be spread on the face, it is recommended to make a zinc “barrier” from the paste. It helps protect healthy skin from possible burns.

The use of the drug has limitations:

• For pregnant;
• For children under seven years old;
• In the presence of individual intolerance to the components of the drug.

In other cases, with proper treatment of the problem area, Feresol effectively helps to cope with anomalies and does not leave scars or stains.

Verrucacid

Aggressive means for cauterizing warts are designed to combat various types of warts - filiform, plantar, and common. These solutions include Verrucacid, a medicine that causes protein coagulation and necrosis of skin growth tissue.

This liquid can burn the epidermis very strongly, so it must be used with extreme caution. If it gets on healthy tissue, it should be immediately wiped off, poured with alcohol and rinsed with running water.

Not everyone can use verrucacid for warts. The use of the drug is prohibited:

• Pregnant;
• Children (if the child is under seven years old).

The medicine is not used to destroy formations located on the mucous membranes. It is not allowed to use a remedy for warts on the arms, legs, or face if the growths are multiple and their area occupies more than twenty square centimeters of the epidermis.

Solcoderm

Some drugs are so powerful that they are only available with a doctor's prescription. One of them is the medicine for warts Solcoderm. It is sold in ampoules. One piece is enough to destroy seven skin growths.

Application requires serious approach

The four acids in its composition allow Solcoderm to effectively cauterize warts. Their impact is so strong that the treated skin becomes necrotic, changes color and falls off.

When using Solcoderm for warts at home, you must follow several rules:

• Do not treat problem areas on the face;
• Do not use to treat children;
• Do not apply to tubercles that appear in the genital area and anus;
• Do not allow the solution to come into contact with acne or moles.

If these instructions are not followed, the wart remover may cause very severe burns. If this happens, you should immediately wash the affected skin with water and immediately go to the hospital.

Collomak

An effective remedy for warts can not only burn them, but also soften them. Collomak is able to remove skin abnormalities in this way. To achieve the desired result, the problem area is treated with medicine up to three times a day. Applying one drop against warts is enough for the effect to become noticeable within a week.

In rare cases, the use of the drug has side effects:

• Redness;
• Burning;
• Local allergic reactions.

The use of Collomak for warts is not permitted if they are hairy. The drug cannot be used to remove growths on the face and genitals.

Some solutions for warts are almost always available at home. This applies to iodine, a multifunctional drug. It can successfully cauterize and destroy abnormal skin formations.

To remove warts with iodine, no special tricks are required. An ordinary cotton swab is dipped into the solution and the problem area is coated with it. Treatment of warts with iodine is carried out at least twice a day (ideally five). After all, the medicine is very quickly absorbed into the tissues and absorbed into the blood.

How does the drug act on papillomavirus?

The medication is produced in the form of a solution, which consists of concentrated acids. When the wart is lubricated, the liquid penetrates deep into its cells, burns, causes dehydration and, as a result, the wart dries out and falls off.

Treatment with a solution is the application of a burn to the mutated tissue. The process of necrosis can be tracked by a change in the color of the growth, which should become gray-yellow over time. As soon as this shade appears, treatment is no longer required, you must wait until the papilla separates.

The drug does not cause toxic poisoning to the body as a whole, it acts locally.

Creams, gels, ointments

Doctors recommend using wart remedies that are not only available in liquid form. Pharmacies sell many drugs with a thicker base. Popular:

Creams, gels and ointments for warts have a more gentle effect than solutions. However, they must also be used extremely carefully.

Vartox

Products for removing plantar warts are very popular. Among them, Vartox is especially distinguished (some mistakenly call the medicine “vortex”). This wart cream is keratolytic in nature. It helps to get rid of the problem well and is characterized by:

Effective in the treatment of plantar warts

• Affordable price;
• Economical;
• Security;
• Painless.

The wart remover is applied to the plantar lesion. The area coated with Vartox is covered with a piece of cotton wool and sealed with an adhesive plaster. After this, the problem area should not be wetted with water. After a day, the overlay is removed.

If necessary, the remedy for plantar warts is applied again. The procedure can be repeated up to five times.

Panavir

A good product, developed by Russian scientists, is made on a plant basis. This is Panavir anti-wart gel. The drug fights not only the skin lesion itself, but also the HPV that caused it.

The medicine for warts Panavir blocks the division of viral cells. In addition, the drug used has:

• High efficiency;
• Low toxicity;
• No side effects;
• Painless.

The wart remover Panavir is applied to the problem area and spread in a thin layer. The gel should be completely absorbed into the skin. The treatment is repeated five times a day for ten days.

Panavir has absolutely no contraindications. It can be safely used by pregnant and lactating women and small children.

Viferon

Topical preparations for warts that have an immunomodulatory antiviral effect are popular. One of them is Viferon.

This ointment is used for warts on the feet, hands, and face. The formations are lubricated two to four times a day. If there are several problematic growths on the epidermis, they are treated simultaneously.

When using Viferon for warts, you should remember that the time frame for getting rid of the anomaly is individual for each person. They are influenced by the type and size of the formation, as well as the depth of the epithelial layers affected by the virus.

Acyclovir

Some patients use medications that are not intended for this purpose as an ointment against warts. These drugs include Acyclovir.

The medication copes well with various herpes and lichen viruses. It is not recommended to use Acyclovir for warts, since its effectiveness in the fight against HPV is questionable.

Salicylic ointment

Some simple and cheap means for removing warts are not inferior in their properties to expensive and advertised drugs. These include Salicylic ointment. A small amount of medicine can treat all types of skin growths. The effective use of ointment for warts on the legs, arms, and neck is noted. Care should be taken to remove formations localized on the face.

Salicylic ointment for warts is applied to the problem area and covered with a piece of bandage. The treatment is repeated three times a day for a month.

Getting rid of plantar warts with Salicylic ointment may take a little longer. It is recommended to apply the product until the tubercle completely disappears.

Real reviews of Solcoseryl for treating wounds after removal of papillomas

Solcoseryl has collected quite a lot of reviews on the Internet. Most of them concern use not for dermatological, but for cosmetic purposes. However, there are also reviews regarding the use of the drug as a complex therapy for the removal of tumors caused by the human papillomavirus.

Irina, 27 years old

I was looking for a drug for tissue regeneration after removal of papilloma on the face. I had a vulgar wart under my cheekbone that attracted attention. Such a defect on a young woman’s face looks very unattractive, so I decided on a radical method to remove it. Although many recommended that I use medications, I went for laser removal because I was afraid that the chemicals might burn the area around the tumor and then leave a mark. And the trace remained just from laser removal. The wound was small, but quite noticeable, and it also took a long time to heal. Then, on the Internet, I came across an article about the product Solcoseryl after removing papillomas. I first purchased it in gel form. However, its use caused me a little discomfort - it burned a little when applied and then the treated area ached a little for some time. That’s when I purchased the ointment, since it contains a lower concentration of the active substance. And already using this product was comfortable for me, without any side effects. I applied the ointment 3 times a day. Although the instructions say that you need to do it twice, I really wanted to forget about my problem as quickly as possible. I applied it in the morning, at lunch and in the evening. As a result, after 2 weeks it seemed to me that I had never had a wart or had it removed. I find this product truly magical. And I am very grateful to the manufacturers for helping me not leave any marks or scars on my face. My pigmentation hasn't even changed.

Maria Pavlovna, 69 years old

I had several senile keratomas on my face. They looked very ugly - large, dark brown growths, with a rather loose structure, and also not tightly adjacent to the skin. My daughter had long insisted on having them removed at a beauty salon, but I was afraid, because one of my friends, who accidentally removed a similar formation, developed melanoma. I went to a dermatologist, who assured me that when removing these keratomas, I should not be afraid of degeneration into cancer, provided that this is done by a medical specialist or a qualified cosmetologist. And I made up my mind. After removal, small wounds remained, which began to scar as they healed. The most popular remedy for scars is Contractubex ointment. But it is very expensive and is not always effective, according to reviews. Then I decided to use Solcoseryl, which one of my friends had previously used. I read the instructions and, strictly following them, began using the ointment. Since the composition did not contain aggressive substances that could harm the skin, I did not treat the wounds pointwise, but simply smeared their halo with my finger, and also went over healthy skin. Imagine my surprise when, after a month, not only was there no trace left of the removed papillomas at the treatment site, but also pigment spots disappeared, wrinkles smoothed out and pores narrowed! After that, I purchased another tube of Solcoseryl and now I constantly use it as a remedy for wrinkles. My dermatologist says that this product is not easy, so it’s not worth using it like this, unless absolutely necessary, and on an ongoing basis. But I want to prolong my youth so much that I take risks. In addition, I had a lot of papillomas all over my body - under my breasts, on my neck and armpits. I've had them for decades and haven't removed them. After getting acquainted with the drug, I removed all the tumors with chemical acids and healed the remaining wounds with ointment. There was not a single trace of tumors left anywhere on my body. Now I always have this ointment in my medicine cabinet.

Cryopreparation

A pharmaceutical product for removing warts can be analogous to an outpatient procedure - cryodestruction. The drug CryoPharma, which is based on refrigerants, has a freezing effect.

This medicine for warts and papillomas is sold together with special applicators. They apply a medicinal composition that can freeze the growth on the skin.

CryoPharma is used for various types of warts:

For the smallest formations, the use of the drug should not exceed forty seconds. If the sole or foot is treated, the exposure time increases.

The can of CryoPharma must be vertical. The composition inside is explosive. It should not be given to children or stored near open flames.

Only a doctor can choose the best remedy for warts. However, it should be remembered that the fastest way to get rid of skin growths is through their complex treatment. To do this, topical medications for warts are taken together with Isoprinosine tablets. You can find out how much the oral drug costs at the pharmacy, but on average the price fluctuates around four hundred rubles.

Dosage

Solcoderm is for external use only; The procedure must be performed by a physician or qualified medical personnel under the supervision of a physician.

Before the procedure, the area of ​​the affected skin is treated with ethyl alcohol or ether. Solcoderm is applied directly to the affected area of ​​the skin. To apply the drug to the skin, use a special plastic applicator with sharp and blunt ends, available in the package. The sharp edge is used mainly for applying the drug to small affected areas of the skin; The blunt end is used to treat large lesions.

As an alternative method of applying the drug, the supplied glass capillary is used. Combined skin lesions with an area of ​​2-3 cm2 can also be treated using a glass capillary. To fill a glass capillary with the drug, it must be immersed in Solcoderm solution for several minutes. Particular care should be taken during application, avoiding applying too large volumes of Solcoderm solution and damaging the deep layers of tissue. It is necessary to apply as much solution as the tissue of the affected skin area absorbs.

Solcoderm is carefully applied to the affected area of ​​skin with a plastic applicator or glass capillary and then distributed over the surface of the selected area of ​​skin with light pressure using a plastic applicator until the solution completely penetrates the tissue. Over the next 3-5 minutes, it is necessary to carefully observe the changes occurring in the treated area: skin discoloration occurs with the appearance of a characteristic pale grayish or yellowish tint. The procedure should be repeated until the above changes in skin color occur.

When treating keratinized warts, the top layer of the stratum corneum should first be removed.

Affected areas of skin with a diameter of more than 10 mm are treated with Solcoderm only if it is established that only the top layer of skin is pathologically modified.

In the presence of numerous foci of skin lesions, treatment with Solcoderm should be carried out in several stages, with an interval of approximately 4 weeks. During each procedure, no more than 2-3 lesions with a total area of ​​no more than 2-3 cm 2 can be treated.

Within a few days after the procedure, the treated area of ​​skin becomes dark brown and dries out to form a scab. In case of unsatisfactory mummification of pathologically altered tissue, the procedure can be repeated after a few days.

In order to promote fixation and mummification of pathologically altered tissues that have undergone treatment, the affected areas should be treated 2-3 times a day with a swab moistened with a 70% solution of ethyl alcohol (especially after taking a bath or after washing).

Do not remove the scab by scraping or using mechanical means. The scab must fall off spontaneously, otherwise tissue healing processes may be disrupted and scars may form.

Composition and action of Solcoderm

The main active ingredient of the drug is nitric acid, additional ones are copper nitrate, oxalic, lactic and acetic acid. The basis of the solution is purified water, which softens the effect of the drug and reduces the acid concentration.

How to use Solcoderm

Solcoderm is intended for external use. It can only be applied by medical professionals strictly in accordance with the instructions, therefore self-medication is prohibited. The procedure itself can be carried out independently, but only under the supervision of a doctor. Each application is carried out from a new ampoule; when opened, the solution does not last long and cannot be used.

Indications and contraindications

Removing formations with Solcoderm solution is a relatively aggressive treatment option, since the concentration of the drug is high, but effectiveness occurs only if it is used correctly.

Side effects

Side effects of the drug can occur if the drug is used incorrectly, as well as contraindications are ignored. The least risk is an allergic reaction to a local product; there may also be irritation, redness, peeling and swelling of the skin in areas close to the site of application of the drug. Serious side effects in case of overdose:

• chemical burn of a large area of ​​skin;
• ulcerative lesion, local necrosis;
• scar formation with individual tendency, infection.

The choice of such treatment must be seriously justified; the course of removal with Solcoderm is prescribed and carried out by a doctor, but the effectiveness is somewhat higher than other local methods. Removing warts with Solcoderm, as reviews say, quickly rids the skin of the defect and leaves no traces.

Side effects

Side effects include short-term discomfort in the form of a burning sensation, which lasts the first few minutes after applying the drug. There is a change in the color of the fabrics to a whitish, gray and yellow tint. This fact is considered the norm. After the mummified tumors fall off and the wounds heal, darkening of the skin and the formation of scar tissue may occur.

An overdose of Solcoderm can lead to deep damage to the skin. The consequence of applying too much medicinal liquid to the affected areas may be the presence of noticeable scars on the skin.

We recommend reading:

1. Radio wave method for removing condylomas
2. What to do with white papules on the face and body?
3. Why do perianal condylomas occur and how to treat them?

Solcoderm in the treatment of pathology caused by the human papillomavirus

The problem of diagnosing and treating diseases caused by the human papillomavirus (HPV) has attracted increasing attention in recent years due to the sharp increase in incidence, the significant contagiousness of the virus and its proven high oncogenicity. During mass studies in Europe, the human papillomavirus was found in 40 - 50 % of cases among those examined aged 15 to 49 years. However, from 5 to 20% of cases, patients require therapy.

HPVs are small DNA viruses, the characteristic feature of which is the ability to cause proliferation of the epithelium of the skin and/or mucous membranes. They belong to the papovavirus (Papova) family. The term Papova Viridae is formed from the first syllables of the names of viruses: pa (pa-) - papilloma virus (papilloma), po (- ro) - polyoma virus (polyema), va (- va) - monkey vacuolating virus. Currently, about 180 types of this virus (Human papillomavirus) are known, which differ in the degree of oncogenicity and preferences for topical presentation.

Papillomaviruses are the only group of viruses that induce the formation of tumors in humans under natural conditions (regardless of the immunosuppressive conditions of the body). In this regard, special control should be placed on processes caused by types of viruses belonging to a “high degree” of oncogenic risk: 16, 18, 39, 45, 46, 56, 59, 68, 73, 82, as well as their presence in combination with viruses 6 and 11 types. These oncogenic viruses often create keratinocytes with an unlimited life span. Special predisposition factors to malignant pathology of epithelial cells include, first of all, gene polymorphism of the human papillomavirus, as well as mutations of some genes in the body of patients. Mutations of HPV genes (gene variants E2, E6 - E7) in patients often determine an increased risk of precancerous pathology, which becomes possible as a result of modulation of replication and integration of the virus into the human genome. Moreover, it is the oncoproteins that determine the processes of malignancy in HPV-infected epithelial cells (interaction with the tumor suppressor protein Rb105, cyclin proteins and DNA repair enzymes). They induce systemic immunosuppression, reducing the immune response (suppressing the expression of major histocompatibility complex genes, inhibiting the maturation of antigen-presenting cells), and also cause local immunosuppression, inhibiting the antiproliferative and antiviral activity of interferons. The duration of infection of the human body with HPV creates conditions for the realization of its oncogenic potential.

The most common clinical manifestations of HPV infection are presented in the table. As a rule, each of the clinical forms is associated with a specific type of HPV.

There are clinical forms (visible to the naked eye or invisible, but in the presence of appropriate symptoms): warts (plantar, vulgar, flat, filiform (acrochorids), verrucous epidermodysplasia, papillomas of the larynx and/or oral mucosa, genital warts, giant condyloma of Buschke-Levenshtein ). In addition, subclinical forms are determined (not visible to the naked eye and asymptomatic, detected only by colposcopy and/or cytological or histological examination), as well as latent forms (the absence of morphological or histological changes when HPV DNA is detected).

Among the options for diagnosing HPV, you should indicate:

- clinical - visual - routine examination + adding a test with 3 -5% acetic acid and Lugol's solution ;

— cytological method (examination of smears according to Papanicolaou or staining of smears according to Romanovsky-Giemsa. It has low sensitivity (50-80%);

— histological examination of biopsy specimens;

- colposcopy (a study that allows you to assess the size and location of the lesion and exclude invasive cancer);

— determination of antibodies to HPV. To more accurately predict the clinical outcome of pathological changes in the cervix and identify the disease at an early stage, additional examinations are required, such as DNA diagnostics;

— molecular genetic methods (DNA diagnostics: determination of the human papillomavirus genome and typing of oncogenic and non-oncogenic pathogens — quantitative and screening PCR diagnostics). Real - Time PCR, Consensus PCR, NS - II.

Knowledge of the presence of tiny amounts of HPV DNA, obtained by high-quality PCR, is not sufficient for clinical practice today, because most patients may be HPV positive. In 70% of cases, virus carriage resolves spontaneously and it is not always possible to make a prognosis regarding the course of human papillomavirus infection based on PCR. A method that allows you to determine the viral load of HPV (in particular, the Digene test) has undoubted advantages, since all the main (13) highly oncogenic types of HPV are detected, and it is also possible to determine the clinically significant concentration of DNA in the tissue, which can serve as a prognostic criterion for the development of the disease and formulate the doctor’s tactics in each specific situation. Invasive cancer is registered on average at the age of 49 years, when additional immuno-hormonal changes occur that promote active invasion and metastasis.

Today, the following classification of therapy methods is optimal: destructive (physical: surgical excision, electrosurgical methods, cryotherapy, laser therapy); chemical (feresol; hydrogen peroxide; solutions of quinine and hingamine; preparations based on salicylic and lactic acids, trichloroacetic, nitric and acetic acids; thuja and celandine juices; Solcoderm ); cytotoxic drugs (podophyllin, podophyllotoxin, 5-fluorouracil); immunological and combined options.

Among the chemicals used in our country and abroad that have a destructive effect, about which sufficient positive information is presented in the literature, one can highlight trichloroacetic and nitric acids, as well as a combined acid preparation - solcoderm.

Solcoderm is an aqueous solution (0.2 ml in an ampoule, 1 piece per package), the active component of which is the reaction products of organic acids (acetic, oxalic and lactic) and metal ions (copper nitrate trihydrate) with nitric acid. Its mechanism of action is based on the oxidation reaction of nitric acid and its intermediate products.

The properties and mechanism of action of Solcoderm distinguish it from other destructive methods. When applied topically, Solcoderm causes immediate intravital fixation of the tissue to which it is applied. The effect of the drug is strictly limited to the place of application. A sign of an immediate effect is a change in the color of the treated area. The devitalized tissue dries out, darkens (mummifies) and a dense black-brown scab forms, which is rejected on its own over the next few days. The destruction caused by Solcoderm is based on intravital fixation with preservation of the basic structure of the neoplasm. In this case, there is no hydrolysis of the peptide bonds of proteins, leading to the dissolution of tissues. Considering that nitrous oxide (NO) plays an important role in protecting the body from bacteria, fungi and protozoa, which often accompany and support viral pathology, conditions are created to reduce the number of relapses of the disease, which determines the effectiveness of this drug. It is very important that with this mechanism of action only minor damage to the surrounding tissue is observed and no systemic resorptive effect is noted.

The healing process is short and complications (secondary infection or scarring) are rare. The therapy is practically painless and is carried out on an outpatient basis, as it does not require special equipment, but is applied with a glass capillary included in the package. After applying a small amount of the drug with a capillary tube, light pressure with a special plastic applicator facilitates its penetration into the tissue. The duration of the procedure is 15 minutes. Therapy for small lesions usually requires one treatment session. When treating large lesions - from 2 to 4 sessions.

The effectiveness of Solcoderm in the treatment of patients with various benign neoplastic formations of the skin and mucous membranes in the form of common or plantar warts is 85 - 94%, genital warts 80 - 87%, seborrheic keratosis 75 - 100% and actinokeratosis 80 - 100%, non-cellular nevus (with confirmed good quality) 98 - 100%. Demonstration of such high efficiency in the presence of safety, availability and ease of implementation of the therapy method allows us to recommend this drug for use in clinical practice.

S.V. Batyrshina

GOU DPO KSMA Roszdrav, Kazan

Tags:Batyrshina, Human papillomavirus, HPV, MedFarmVestnik Povolzhya 06 (24.02.10)

"Solcoderm": contraindications for use

Are there any conditions for which it is not recommended to use Solcoderm? Reviews indicate such contraindications for this drug as a tendency to cause scars. Malignant neoplasms on the skin that are prone to metastases are also prohibited. It should also not be used to combat keloid scars and freckles.