Vaccine against human papillomavirus ()
Recombinant adsorbed vaccine for the prevention of diseases caused by human papillomaviruses, containing adjuvant AS04. It is a mixture of virus-like particles of recombinant surface proteins of human papillomavirus types 16 and 18, the effect of which is enhanced by the AS04 adjuvant system.
L1 proteins of human papillomavirus types 16 and 18 were obtained using recombinant baculoviruses of human papillomavirus types 16 and 18 in Trichoplusia ni cell culture (Hi-5 Rix4446). AS04 consists of aluminum hydroxide and 3-O-desacyl-4′-monophosphoryl lipid A (MPL).
According to epidemiological data, most cases of cervical cancer are caused by oncogenic human papillomaviruses. Human papillomavirus types 16 and 18 are responsible for more than 70% of cervical cancer cases and approximately 50% of all cases of cervical intraepithelial lesions worldwide.
Clinical effectiveness
The effectiveness of the drug against human papillomavirus types 16 and 18 and the consequences associated with infection was confirmed by clinical studies that included 1113 individuals aged 15-25 years. A combined analysis of the study results and 4-year follow-up showed:
— 94.7% effectiveness in preventing infection (95% CI: 83.5; 98.9);
- 96.0% effectiveness against cervical infection that persists for at least 6 months (95% CI: 75.2; 99.9);
- 100% effective against cervical infection that persists for at least 12 months (95% CI: 52.2);
— 95.7% effectiveness against human papillomavirus infection detected at the stage of cytological abnormalities* (95% CI: 83.5; 99.5);
— 100% protection against the development of human papillomavirus infection, detected histologically, at stage CIN1+** (95% CI: 42.4; 100);
— 100% protection against the development of human papillomavirus infection, detected histologically, at stage CIN2+*** (95% CI: -7.7; 100).
* Cytological abnormalities include atypical squamous cells of undetermined significance (ASC-US), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), and the presence of atypical squamous cells in which HSIL cannot be ruled out (ASC- H).
** CIN1+ - cervical intraepithelial neoplasia grade 1 and higher.
*** CIN2+ - cervical intraepithelial neoplasia grade 2 or higher.
The vaccine provides cross-protection in 40.6% of vaccinated persons against any manifestations of cytologically detected human papillomavirus infection caused by other oncogenic types of human papillomavirus (95% CI: 14.9; 58.8). The vaccine is effective against the development of any CIN2 lesions (regardless of human papillomavirus deoxyribonucleic acid type) in 73.3% of subjects (95% CI: -1.0, 95.2).
Before it’s too late: boys will be vaccinated against HPV in Russia. For what?
In this case, the virus does not simply accumulate, but evolves in the cell, which can then turn into precancerous cells and lead to the development of oncology. It is these lesions that require special therapy to prevent the development of cancer.
Purely historically, cases of such cancer were relatively rare until some time. But a lot has changed with the spread of HIV infection, and now this type of cancer in HIV-positive people from the MSM category is not at all a rare occurrence.
Cervical cancer is the number one killer of women with HPV. As a rule, the prevalence of this type of cancer is higher in those countries where there is no regular cytological screening and no HPV screening - the number of cases there reaches 65 per 100 thousand population.
And the incidence of anal cancer in the general population is approximately 2 cases per 100 thousand population. Among HIV-positive individuals in North America and MSM, this is approximately 131 cases. Among men who have sex with women who have never had anal sexual contact, there are 46. Among women, this is 30 per 100 thousand.
Moreover, after antiretroviral therapy became available, unfortunately, the incidence of anal cancer did not change. On the contrary, something completely opposite happened. Since 1996, when antiretroviral therapy became available in North America, statistics have only gone up. One of the reasons for this is that people are living much longer. This type of cancer usually takes a very long time to develop, and therefore the longer we live, the more likely it is that this can happen to us.
In addition, there are suggestions that in the HIV scenario, events occur somewhat accelerated - due to accelerated biological aging. So now we can say: approximately 10% of men who have sex with men are at risk of developing cancer.
Vaccination against HPV
The main methods of combating the disease remain screening, removal of infection and other methods of influencing the high degree of intraepithelial neoplasia of these lesions.
We know it works for the cervix, which is why cervical cytology screening is done in women. And we hope this will work for anal cancer as well. A separate issue is vaccination. I know that HPV vaccination here in Russia among men is not routine, standard practice.
The vaccines that have been developed so far are preventive vaccines. That is, it is ideally supposed to vaccinate individuals at risk before possible infection occurs.
If infection has already occurred and then there was vaccination, this is unlikely to help. At the moment, three types of drugs are available to us. But the main one is the quadrivalent vaccine. It contains genes from HPV type 6, HPV type 11, HPV type 16, HPV type 18.
Why did you choose these types? Because it is the sixth and eighteenth types that most often lead to the development of cancer, that is, they are the most oncogenic. The sixth and eleventh types were added to them in order to prevent the development of genital warts and genital warts.
Some states in North America and other countries also have a nine-valent vaccine, which contains 5 more types that are added to the standard quadrivalent Gardasil vaccine. This is another 20% protection against the development of cervical cancer. But adding 5 more types for anal cancers did not make a big difference. Since most anal cancers are usually associated with HPV type 16.
Everything about pregnancy planning, as well as pregnancy, childbirth and children
Since 2009, tens of thousands of girls in the Russian Federation have been given free American vaccines that cause infertility.
Since 2009, all clinics, schools and private medical centers began to offer the female population of our country a new way to prevent cervical cancer - vaccination against the human papillomavirus (HPV). According to the developed vaccination program, only girls and women of the childbearing period from 12 to 50 years. Let's remember this fact. Let us also remember that this virus affects men as often as women, but strangely enough, they are in no hurry to vaccinate them.
The proverb “free cheese only comes in a mousetrap” did not appear out of nowhere. Especially in Russia. And then in 2007-2008, Dmitry Medvedev approved a pilot project to vaccinate 15,000 Russian girls over thirteen years old with the Gardasil vaccine (USA) in Moscow, the Moscow region and Khanty-Mansi Autonomous Okrug. In Khanty-Mansiysk Autonomous Okrug alone, 42 million rubles worth of vaccines were purchased for this purpose. The idea is good (these are usually used in pavements, when building a highway to hell) - salvation from cervical cancer.
Later, interesting independent studies began to appear:
“There was no significant evidence of a therapeutic effect of the vaccine in analyzes of women who received all doses of the vaccine compared with analyzes of women who had only HPV infection. We found no evidence of vaccine effectiveness. Vaccination does not affect the rate of viral clearance over a 12-month period. Further research into the effectiveness of the BLA (biologics license application) found that Gardasil may increase the risk of disease by 44.6% in certain people, namely those who are already carriers of the HPV types used in the vaccine."
Simply put, it was not possible to detect a positive effect from the vaccine, but there is a negative effect - acceleration of precancerous changes if the girl is already a carrier of the HPV virus. In addition, the three-stage vaccination procedure is suspiciously similar to the vaccines developed by the Rockefeller Foundation to induce miscarriages. And we still do not take into account the regular consequences of the Gardasil vaccination:
As of September 28, 2010, the Vaccine Advers Events Reporting System (VAERS) has recorded more than 18,000 cases of complications after receiving Gardasil, including at least 65 deaths.
UPD. And here is the data as of November 23, 2010. There are already 20,432 complications and 85 deaths. Those. in less than a month there were 2432 complications and 20 deaths. And this is only for Gardasil - Cervavix has its own statistics. The very possibility of cure with drugs is also questioned:
Gardasil is NOT a cancer vaccine. This is just a vaccine against two strains of human papillomavirus, which can lead to cervical cancer in some cases in some women. Because there are at least 15 strains of human papillomavirus that can cause cancer, vaccinated girls may get it from one of 13 infections not covered by the vaccine. The vaccine does not provide protection if infection with one of the strains contained in it occurred before vaccination.
Nine British girls are suffering horrific adverse reactions to the cervical cancer vaccine Cervarix.
Website "The Truth About Gardasil" (USA)
VAERS reports 41 cases of cervical cancer after Gardasil vaccination!
There are many facts about the negative consequences of using Gardasil. Testimonies of victims.
It turns out to be an interesting picture. The United States, which mainly finances revolutions, suddenly begins to massively help third world countries by supplying tens of thousands of doses of the Gardasil and Cervarix vaccines. Personally, I see here the main and secondary factors-causes. 1) financial benefit - vaccination with drugs at the state level is billions of dollars, and Gardasil and Cervarix collect these billions 2) secondary - this is population reduction by provoking infertility in women of reproductive age.
I live in Yekaterinburg myself. And here are easily found links to the placement of Cervarix in the Urals Federal District:
July 21, 2011
Today, the clinics of Children's City Hospital No. 11 can supply the drug Cervarix. The vaccine is intended to prevent cervical cancer. It is given to girls aged 10 years. Vaccination with Cervarix is completely free.
June 7, 2011
A free vaccine against cervical cancer has arrived in the Sverdlovsk region. This was reported by the regional Office of Rospotrebnadzor. As part of humanitarian assistance, GlaxoSmithKline Trading sent 17 thousand doses of the Cervarix vaccine to the Middle Urals to prevent cervical cancer. It is planned that this vaccine will be enough to carry out double immunization of more than 8 thousand girls aged 10-18 years in 27 municipalities in the Sverdlovsk region.
June 20, 2011
The Central City Hospital will receive free vaccines against cervical cancer.
So, in 2011, Yekaterinburg received 17,000 doses of the drug Cervarix - free of charge, as a gift from the United States. Vaccinations are given in the largest clinics in Yekaterinburg, both public (Central City Hospital) and private (New Hospital). This is one fact. Second, according to statistics in Russia, 60% of pregnancies end in abortion. Wherein:
A 16-year-old girl became infertile due to the Gardasil vaccine. After vaccination, premature menopause began.
Data published by VAERS shows that Gardasil is by far the most dangerous vaccine. Given during pregnancy, it has caused more than 1,300 adverse reactions in its five years of existence, compared with the next most dangerous vaccine often given to pregnant women, the flu vaccine, which has caused 200 adverse reactions in the past 20 years. Gardasil vaccination during pregnancy has also been associated with both increased miscarriages and high rates of birth defects.
And now the most interesting thing - in 2011, HPV vaccinations (Gardasil and Cervarix) were banned in India and France. At the same time, free state vaccination with Gardasil began in Russia; in 2011, 17,000 doses arrived in Yekaterinburg alone.
Draw your own conclusions.
Vaccination is the only protection against human papillomavirus infection
23.10.2018
More than 6,000 women die from cervical cancer every year. This terrible disease, one of the most insidious types of cancer, is caused by the human papillomavirus, for which there is currently no cure. Experts around the world have already recognized that even the most effective screening program cannot affect the spread of human papillomavirus infection, which remains the leading cause of cancer in women around the world. Only effective and safe vaccination will prevent the disease and provide reasonable hope for success in the fight against cervical cancer. Is it possible to prevent HPV infection?
In the 90s of the last century, German virologist Harald zur Hausen first developed a vaccine for the primary prevention of cervical cancer, for which he was awarded the Nobel Prize in 2008.
Today it is possible to prevent HPV infection with timely vaccination. Informed means armed!
The human papillomavirus is very widespread.
Every year, up to 500,000 cases of cervical cancer are diagnosed worldwide, killing more than 250,000 women. More than 80% of new cases occur in developing countries, where this type of cancer is the leading cause of death from cancer in women. In developed countries, despite a wide range of diagnostic programs, cervical cancer ranks second among cancer diseases and among the causes of death in young women under 26 years of age. In addition, HPV infection often manifests itself as the development of unpleasant and aesthetically unattractive genital warts. According to WHO, 30 million cases of genital warts are registered every year. Currently, there are no effective and proven methods for treating infection caused by the human papillomavirus, so the only effective and scientifically proven way to prevent it is vaccination. The World Health Organization recommends including routine vaccination against human papillomavirus infection in national immunization programs. Today, in the USA, Austria, Australia and New Zealand, mass vaccination of adolescents of both sexes is carried out as part of the national immunization program. In the USA, vaccination is carried out among all girls from 11-12 years old, in France - from 11 years old, in Germany - from 12-17 years old, in Austria - from 9-17 years old. World experience in the use of these vaccines for several years has shown their safety and high preventive effectiveness. The vaccine against human papillomavirus is created using recombinant technology - this is a new direction in the production of medical drugs. Vaccines obtained using this technology are effective and safe. What HPV vaccines are there?
Currently, two vaccines against HPV have been synthesized: the bivalent HPV-16/18 vaccine and the quadrivalent HPV-16/18/6/11 vaccine.
In large studies involving tens of thousands of women ages 16 to 26, both vaccines were found to be nearly 100% effective in preventing disease caused by the human papillomavirus. There is evidence of a possible additional protective role of these vaccines against other HPV types not included in the vaccines, so-called cross-immunity. Your doctor will help you choose a vaccine! When to start vaccination?
Girls and women are vaccinated between the ages of 9 and 45 years. Boys and men are vaccinated between the ages of 9 and 26 years. The vaccination is done three times. The interval between the first and second is two months, between the second and third is four months. Timely vaccination will help you avoid many problems in the future! When deciding on choosing a clinic for vaccination, it is important to trust your health and that of your family to professionals with many years of experience. In the MEDSI network of clinics you can carry out timely vaccinations and get answers from doctors to all your questions on this topic. Vaccination using the Gardsasil vaccine is carried out in the following MEDSI clinics: clinical diagnostic center on Krasnaya Presnya, children's clinic on Pirogovskaya, children's clinic on Blagoveshchensky Lane, clinic in Krasnogorsk, clinic in Mitino, blade on Leninsky Prospekt, clinic in Khoroshevsky Proezd.
