Triderm ointment is a triple-action drug with antibiotic and hormone

Triderm ointment is a remedy for the treatment of skin infections. The instructions stipulate that the ointment must be prescribed by a doctor, and sometimes it is necessary to replace it with a simpler analogue. The Triderm composition was developed for the treatment of complicated dermatitis. The indication for treatment is the addition of a bacterial and fungal infection to existing allergic skin inflammation (dermatitis or eczema) . It is important to understand that Triderm is a potent drug and can only be used for specific symptoms. When is Triderm ointment really necessary? And why can’t it treat any skin inflammation?

Compound

The pharmaceutical product called Triderm is produced by SCHERING-PLOUGH LABO NV, whose production facilities are located in Portugal and Belgium. And there is also a drug jointly produced by Italy and the USA. The product is available in the form of a cream or ointment. Sold in tubes of 15 g, 30 g.

Both forms of the product have a similar composition and concentration of active components.

1. Betamethasone dipropionate;
2. Gentamicin;
3. Clotrimazole.

Among the auxiliary components for the ointment, Vaseline and liquid paraffin are used. In addition to these substances, the cream contains many others:

• Macrogol;
• Cetostearyl, benzyl alcohol;
• Phosphoric acid;
• Propylene glycol;
• Hydroxide, sodium dihydrate.

Additional substances create a certain consistency and change the rate of absorption. The ointment remains on the surface of the skin longer, prolonging the duration of exposure. The cream is absorbed faster, the effect occurs earlier, but lasts less.

Cream "Triderm"

The composition of the main substances is identical. It includes quantitatively and qualitatively the same substances:

1. Gentamicin is an antibiotic. Powerful in its action, it helps to destroy the pathogenic environment. Content – ​​1 mg/g.
2. Glucocorticoid betamethasone is a hormonal agent. Perfectly relieves inflammation, redness in areas of the skin and itching. Content – ​​0.5 mg/g.
3. The antimycotic clotrimazole is a substance that helps in the fight against fungal infections and infections. Content – ​​10 mg/g.

The main difference is the content of excipients. For cream the list is as follows:

• Soft paraffin, Vaseline - creates a thin film when applied to the skin, which helps the substances to be better absorbed and not evaporate.
• Phosphoric acid – protects the cream from oxidation, preservative.
• Macrogol.
• Alcohols.
• Propylene glycol.
• Sodium hydroxide.

Triderm - hormonal drug or not

Everyone knows about the negative effects of hormones when used incorrectly. In most cases, it is impossible to do without potent hormonal ointments. Proper use of corticosteroids gives a quick effect and prolongs periods of calm. But such drugs have a number of contraindications, side effects, and limited use. Is Triderm hormonal?

Triderm cream and ointment contains a potent component, betamethasone dipropionate, which belongs to the group of glucocorticosteroids and is a synthetic hormone. This group is considered very strong, allergic symptoms disappear in a matter of days. Betamethasone eliminates inflammation, relieves itching, burning, and redness.

The active component penetrates the blood, has a systemic effect, and is addictive. With prolonged use, withdrawal syndrome occurs. Treatment should not be stopped abruptly; the dose of hormones should be reduced gradually. Add the corticosteroid to your regular moisturizer, decreasing the dosage daily.

If the recommended terms are violated, Triderm disrupts hormonal levels, causes an allergic reaction, and provokes the development of oral dermatitis, which is much more difficult to get rid of.

Is it possible to use for newborns and infants?

According to the instructions, the medication has three actions: anti-inflammatory, antifungal and antibacterial . The composition contains a hormonal agent - the glucocorticosteroid betamethasone, which is absorbed through the skin into the blood in small doses.

A child under one year old has delicate skin, so betamethasone is absorbed twice as much.

But sometimes doctors prescribe Triderm for newborns, if necessary. For example, with severe allergic or atopic dermatitis, when the benefits outweigh the side effects.

In newborns, Triderm sometimes causes:

• bulging fontanel;
• swelling of the optic nerve;
• headache;
• suppression of the functioning of the adrenal glands, hypothalamus, pituitary gland;
• growth retardation;
• Itsenko-Cushing syndrome;
• growth retardation.

Often, newborns are prescribed not ointment, but cream, since it is less greasy and is quickly absorbed. It does not remain on the skin for long, which eliminates the possibility of smearing and getting the product into the mouth.

Action of Triderm, therapeutic effect

Each component of the drug performs its own functions. As a result, the therapeutic effect occurs within 3 days, the final relief from the symptoms of the disease occurs in 10 days.

1. The main role in relieving inflammation, irritation, itching, and other allergic manifestations is played by the corticosteroid betamethasone. The effect occurs within 24 hours and lasts for about 8 hours. Using the substance for 5 days completely eliminates unpleasant allergic symptoms.
2. Clotrimazole is a strong antifungal agent. Penetrates into the deep layers of the dermis, affects the cells of pathogenic microorganisms, eliminates the source of inflammation.
3. Gentamicin is a broad-spectrum antibiotic. Destroys all pathogenic microflora and does not cause resistance. Always works effectively.

The combined influence of all components gives a quick, lasting therapeutic effect.

pharmachologic effect

Triderm has a complex effect on the disease: suppression of inflammatory and allergic processes is provided by betamethasone, the antibacterial effect is provided by gentamicin, and clotrimazole destroys fungal infection. The drug successfully copes with various types of mycosis, candidiasis, lichen formations, streptococcal and staphylococcal skin infections, Pseudomonas aeruginosa and Escherichia coli, as well as other pathogenic bacteria. In addition, it provides a stable, prolonged effect.

Triderm penetrates the bloodstream in small amounts, but the absorption of the hormone increases greatly when the medication is applied to open wounds or skin lesions. This is a contraindication.

Exceeding the specified dosage and immoderate treatment of the child leads to complex forms of dermatitis and dysfunction of the adrenal cortex. Therefore, therapy must be competent and supervised by the attending physician.

Indications

Triderm cream should not be used during periods of exacerbation of dermatological diseases. The reason for use is the presence of a secondary infection - inflamed spots, weeping, rough areas of the skin. Fungal or bacterial infection manifests itself:

• Allergic, atopic dermatitis;
• Eczema;
• Neurodermatitis;
• Athlete's foot;
• Spread of lichen;
• Dermatomycoses on different parts of the body.

This situation does not allow self-treatment. The epidermis should be examined by a specialist.

Instructions for use

Triderm must be applied to a previously cleaned surface in a thin layer. The affected area of ​​the skin and a small amount of healthy dermis around the inflamed area are treated. Thorough rubbing is not required.

special instructions

• Triderm should not be applied to open wounds, as this increases the intensity of absorption of the antibiotic into the blood. There are side effects from the gastrointestinal tract, nervous system, and autonomic.
• The procedure should be carried out twice a day. If it was not possible to apply the medicine in the morning, you can transfer it to lunch. The duration of therapy depends on the degree of skin damage and the complexity of the disease. You can use Triderm cream and ointment for a month.
• Treatment should not be stopped abruptly. This action leads to relapse within 1-2 weeks. It is necessary to add Triderm to a moisturizer, reducing the concentration of the drug daily. After a week, continue using moisturizer without Triderm.
• If the use of the drug increases negative symptoms, additional antibiotics are prescribed. Including for oral administration.

Overdose

Long-term use of the drug affects the functioning of internal organs and systems. Hormonal levels are disrupted, and renal failure syndrome appears. An overdose is indicated by:

• Obesity;
• Weight gain;
• Thinning of the skin;
• Increased allergic symptoms;
• Amenorrhea;
• Irritability;
• Insomnia;
• Dizziness;
• Disruption of the gastrointestinal tract;
• Frequent heartbeat;
• Growth of microorganisms, spread of infection.

An overdose requires special treatment; it is not enough to simply stop using Triderm.

Composition of Triderm ointment: three in one

Triderm ointment is available in tubes of 15 and 30 g. It contains three active ingredients: an antibiotic, an antifungal agent and a synthetic hormone . Hence the name of the ointment -

Tri-derm
- triple treatment for the skin
.

We will describe in detail how each of the components works and what their combined use in the ointment gives.

Betamethasone is a synthetic hormone

Betamethasone is a synthetic hormone. It provides antiallergic effect. Relieves itching and inflammation caused by an atypical reaction (allergies). What does betamethasone do in cells?

This substance stops the release of inflammatory mediators . Their appearance in the blood is a trigger for any allergic reaction. As a result of an atypical (allergic) reaction to certain substances, the body releases mediators into the blood and forms inflammation.

Betamethasone also constricts blood vessels. By this, it limits the penetration of existing mediators to the site of inflammation. By stopping the release of mediators and constricting blood vessels, the symptoms of skin inflammation weaken and disappear.

Sometimes people doubt whether Triderm is a hormonal ointment or not?

Triderm contains a hormone, therefore it is a hormonal drug. The use of hormones imposes its own characteristics on the treatment process. For example, hormonal ointments should not be discontinued abruptly. It is necessary to reduce the amount of the active substance gradually, over several days, and only then discontinue the ointment completely.

What are other side effects of hormonal treatment?

• Feeling of dryness on the skin.
• Skin discoloration, stretch marks.
• Increased hair growth in areas where hormonal cream and ointment were applied.
• Addiction - if used for several months - the skin gets used to hormonal treatment and stops responding to other medications.

Clotrimazole for fungus

Clotrimazole is an antifungal component. It disrupts the synthesis of substances necessary for the restoration of fungal membranes (shells). Thus, fungal microorganisms are destroyed and die.

Clotrimazole is most effective against three fungal infections - candidiasis, microsporia, trichophytosis (the medical name for ringworm). Triderm ointment is prescribed for these fungi.

Antibiotic Gentamicin

Gentamicin is an antibiotic. It penetrates the bacteria and disrupts protein synthesis in them, stopping their vital activity and further reproduction of pathogenic flora. Gentamicin destroys various pathogenic bacteria - staphylococci or streptococci, Klebsiella, Escherichia coli or Pseudomonas aeruginosa .

Note: the amount of antifungal clotrimazole in Triderm ointment is 10 times greater than the antibacterial gentamicin (10 mg of clotrimazole versus 1 mg of gentamicin). And the content of the hormonal drug is even less - 0.64 mg per 1 g of ointment.

Each of the active ingredients is a toxin. Therefore, the use of ointment requires certain indications - the presence of an infection (bacterial or fungal) against the background of a developed allergic reaction.

Use for children

Children over 2 years of age are allowed to use the drug in any form.

1. In most cases, a cream is recommended. It is absorbed faster, does not remain on the surface of the skin, and does not get into the eyes, nasal mucosa, or mouth. It is allowed to use the cream on small areas of the skin.
2. In case of severe damage or severe form of the disease, ointment is recommended. It is absorbed more slowly and the effect lasts longer. The break between use is observed from 6 to 8 hours.
3. The average duration of therapy is 7 days. An extension of up to 12 days is allowed if there is a positive trend towards recovery. If the desired effect is absent, Triderm is replaced with another drug.

Treatment with Triderm is contraindicated for infants. Since the active components quickly enter the bloodstream through the baby’s delicate skin and spread throughout the body. The risk of side effects increases.

Release form

The drug Triderm is produced in the form of ointment and cream. There is no tablet form. Tubes with the product in volumes of 15 and 30 g are available for sale.

The concentration of the main substance in both masses is equal, but due to the difference in the auxiliary components, the cream has a lighter liquid gel-like consistency of white color. For this reason, it is mistakenly called a gel. It is used in the treatment of mild degrees of dermatitis and mycosis .

Triderm ointment is a pale yellow translucent mass, soft to the touch. It is used to treat severe infections and extensive lesions of the external integument.

The ointment has a minimal amount of additional components, so it is often recommended for allergies and skin hypersensitivity.

Contraindications, side effects

Do not use the drug if you have an individual intolerance to the components. Use is contraindicated in a number of cases:

• Lupus;
• Post-vaccination infection;
• Herpes;
• Syphilis;
• Children under 2 years of age;
• Chicken pox;
• Acute stage of allergic, atopic dermatitis.

Contraindications cannot be ignored, nor can treatment be prescribed spontaneously.

Side effects include skin atrophy, dehydration, weeping, erythema, hyperpigmentation, erythema, burning, and severe itching.

Triderm ointment and cream: instructions for use, price, reviews, analogues, indications and contraindications

Treatment of advanced skin diseases complicated by secondary bacterial infection requires the use of drugs with complex anti-inflammatory, antimicrobial and antifungal effects. These medications include Triderm cream and ointment, prescribed for dermatological diseases of various etiologies.

Release form and composition

Triderm is available in two dosage forms:

The composition and concentration of active components in 1 g of both drugs are similar:

• betamethasone dipropionate - 0.5 mg,
• clotrimazole - 0.01 g,
• gentamicin sulfate - 1 mg.

Triderm ointment is a homogeneous translucent cream-colored substance without foreign inclusions. Vaseline and soft paraffin are used as additional components.

Triderm cream has a consistency similar to a transparent gel with a slightly white tint.

Auxiliary ingredients included in its composition are propylene glycol, benzyl and stearyl alcohols, phosphoric acid, soft paraffin.

Both drugs are packaged in metal tubes of 15 and 30 g, equipped with a foil membrane and closed with a screw-on plastic cap. The tube is packed in a cardboard box, which also contains detailed instructions for using the medicine.

To purchase Triderm at a pharmacy, you do not need a doctor's prescription.

The shelf life of medications provided they are kept in a cool, shaded place: ointments - 24 months, creams - 36 months. The price of the drug is from 750 rubles for 15 g.

pharmachologic effect

Triderm ointment and cream are preparations intended exclusively for external use. The high effectiveness of the product is achieved due to the action of its main components:

• betamethasone is a corticosteroid that relieves inflammation, reduces the manifestations of allergies (itching, rash, erythema, swelling),
• clotrimazole has a detrimental effect on many types and strains of fungal pathogens,
• Gentamicin is an aminoglycoside antibiotic with broad antibacterial activity.

The combination of these substances allows the use of the drug Triderm when affected by the following microorganisms:

• dermatophytes Epidermophyton floccosum, Trichophyton rubrum,
• yeast-like fungi Candida albicans,
• gram-negative bacteria Proteus vulgaris, Pseudomonas aeruginosa,
• gram-positive bacteria Staphylococcus aureus.

When applied locally, an ointment or cream may penetrate the corticosteroid into the systemic bloodstream. The concentration and speed of this process are directly dependent on the location of the lesion, the state of the patient’s immune system, and his age.

Gentamicin can be absorbed into the subcutaneous layer and enter the bloodstream when the medication is used on areas of damaged skin or when applied under an airtight bandage or cast. Clotrimazole, having low absorption, accumulates in the upper layer of skin and keratin of nails and hair.

Indications for use

According to the abstract, indications for the use of the drug Triderm are dermatoses complicated by microbial infection and mycotic contamination.

The list of diseases for which Triderm ointment or cream helps especially effectively includes:

• atopic dermatitis,
• neurodermatitis,
• eczema, including microbial and mycotic,
• dermatophytosis,
• pityriasis versicolor,
• inguinal candidiasis,
• athlete's foot.

Clotrimazole is poorly absorbed into the nail, so Triderm is not effective for onychomycosis.

In addition, the treatment of fungal lesions on the nails requires the application of topical medications over a long period (up to 12 months), which is not possible with this corticosteroid-containing medication. Therefore, it is better to treat nail plate fungus using “lighter” non-hormonal external agents.

Contraindications

The presence of betamethasone in the composition causes a number of contraindications for the use of ointments and creams . These include:

• chickenpox,
• herpes,
• tuberculosis of the skin,
• external manifestations of syphilis,
• the presence of open wounds, abrasions, boils,
• post-vaccination reactions.

Prescribing Triderm is not possible if there is an individual intolerance to one or more of the ingredients included in its composition.

The drug should not be used to treat children under two years of age, or in the first three months after conception.

Due to increased penetration of the hormonal component into the systemic bloodstream, Triderm is not used on large areas of skin and under occlusive dressings.

Directions for use and dosage

The drug should be used only as prescribed by a doctor for the treatment of severe and advanced stages of skin diseases. The product cannot be used in the treatment of diseases of the eyes and periocular area and is not indicated for application to the face .

For the treatment of otitis, Triderm can be used only in emergency, urgent cases and only for short-term exposure. When placing a tampon with medicine in the ear, you need to monitor the body’s reaction so as not to miss unwanted complications.

For adults

If there are no other instructions, the method of using the product is as follows:

• Apply the ointment or cream to a clean, dry surface in an even layer, lightly pressing into the skin with your fingertips.
• It is recommended to carry out two procedures per day - in the morning and in the evening.
• Do not get the medicine into your eyes or mouth. If this happens, rinse with plenty of water and apply symptomatic treatment.
• To get the best effect, apply the ointment or cream regularly.
• The duration of therapy depends on the diagnosis, stage of the disease, general condition of the body and is determined by the doctor individually for each patient.

If after 3 weeks no positive dynamics are observed, additional laboratory tests must be carried out to determine the reasons and possible replacement of the drug.

For children

Betamethasone and gentamicin can cause dangerous systemic adverse reactions in young children. These include dysfunction of the adrenal glands and pituitary gland, which lead to increased intracranial pressure, growth inhibition, and cessation of weight gain.

Therefore, in pediatric practice, Triderm is prescribed only from the age of two. In addition, its use should be carried out strictly in the dosage specified by the doctor and last no more than 7 days.

During pregnancy and lactation

Triderm ointment and cream are not recommended for use in the first 3 months after conception. Further treatment with the drug is possible only under the supervision of an observing obstetrician. In this case, the drug should not be used for more than 7 days and should not be applied simultaneously to large areas of the skin.

If there is a need for treatment with Triderm during lactation, breastfeeding should be stopped.

Overdose

Long-term exposure to the corticosteroid betamethasone, which is part of the drug, can lead to suppression of adrenal function and the appearance of external signs of hypercortisolism - obesity, increased hair growth, changes in skin color.

In this case, the use of Triderm is stopped and treatment is used aimed at eliminating the symptoms that appear and adjusting the balance of liquid electrolytes. As a rule, hypercortisolism in the acute stage is reversible.

Drug interactions

No particularities were noted with the simultaneous use of Triderm and other pharmaceuticals.

Adverse reactions

Unpleasant side symptoms that may appear after applying the medication are associated with the effects of each of the main active components.

1. Betamethasone - dry skin, burning, itching, increased hair growth, changes in pigmentation, acne, maceration, the appearance of stretch marks.
2. Clotrimazole - dehydration of the epidermis, erythema, formation of vesicles, small rashes.
3. Gentamicin - drying and redness of the skin.

If one or more of the listed signs are detected, treatment with Triderm should be suspended and consult a doctor to change the drug.

Analogs

Triderm ointment and cream are considered expensive medicines, but at the pharmacy you can buy products that have a similar composition, but cost less.

These include:

• Akriderm GK - from 340 rubles,
• Kanizon plus - from 200 rubles,
• Triakutan - from 210 rubles.

In case of individual intolerance to the components that make up the drug Triderm, they can be replaced with the following analogues that have a similar effect:

• Belosalik,
• Candiderm,
• Betaderm,
• Rederm,
• Diprosalik,
• Betasal.

At the same time, people with sensitive skin and a tendency to allergic reactions are best suited for ointments that contain a minimum amount of ingredients. A cream with greater absorption and a drying effect can be chosen when applied to wet areas of the skin or under clothing .

Reviews

Reviews will help you form an opinion about the effectiveness of treatment with Triderm. Characteristics of the medication are given not only by patients, but also by dermatologists.

Alexandra, 40 years old

In addition to eczema, which I have been suffering from for several years, I contracted a fungus from my husband. Abscesses began to form on my hands, which were very itchy and painful. The doctor prescribed me Triderm ointment.

Of course, I wasn’t happy with the price at all, but I had to buy it. And when a week later my hands began to heal, I no longer regretted the money spent - health is more valuable.

Ivan Konstantinovich, dermatologist with 23 years of experience

Stepan, 28 years old

I just couldn’t get rid of inguinal dermatomycosis, although I tried many folk remedies and pharmaceutical ointments. They advised me to buy Triderm cream and apply it 2 times a day. Surprisingly, after 5 days all the rashes disappeared, and the skin stopped itching and hurting. Very good product, I'm pleased.

Source: https://fr-dc.ru/kozhnye-zabolevaniya/obzory-preparatov/primenenie-mazi-i-krema-triderm-v-dermatologii

Analogs are cheaper than Triderm

Each pharmacy has a wide range of products for the treatment of dermatological diseases.

External use products with a similar composition of active ingredients and action:

• Akriderm;
• Kanizon plus;
• Betazon Ultra cream;
• Triacutan.

Analogues with the same 2 active components, similarity of action:

• Belogent;
• Betaderm;
• Betazon Plus;
• Celestoderm-B;
• Celederm;
• Kanderm.

Drugs with similar effects:

• Belosalik;
• Betasal;
• Cleore;
• Rederm;
• Elokom-S;
• Betaderm-A.

Similar products are chosen if Triderm is suitable, but the price is not satisfactory. In this case, they buy a drug with an identical composition and a similar effect. Or an allergic reaction has occurred to the drug. Then they purchase a product with a similar effect, but a different composition of active ingredients.

The difference between Triderm and AKRIDERM GK

AKRIDERM GK.
Photo: petroapteka.com The drugs are analogues of each other. The active ingredients are the same in concentration (Betamethasone, Gentamicin and Clotrimazole). They differ in the composition of excipients. Both drugs are approved in pediatrics from 2 years of age. There is also a difference in the purchase of the substance: Triderm components from Spain, Singapore and China; the substances of the drug ACREEDERM GC are produced in China, India, Italy, and Malaysia. Both drugs are over-the-counter!

The country of origin of Triderm is Germany. AKRIDERM GK is produced in Russia. In terms of cost, AKRIDERM GK is cheaper than Triderm. Price per package from 355 rub.

Reviews

You can leave your reviews about Triderm cream, other users will be interested: Alina:

“The child started having problems with allergies when he was 2 months old. Until a year ago, nothing special was prescribed. After 6 months Advantan was allowed. There was no particular result. After 2-3 weeks everything happened again. Allergic manifestations always intensified on the legs after colds, and we were sick a week later. At the age of 2, I was hospitalized with poisoning. After the course of treatment, the allergy worsened so much. Weeping and inflamed lesions appeared. I read that corticosteroids can no longer be used in this case; antibiotics are needed. I bought Triderm. The very next day I noticed an improvement. Within a month, the skin became clear, which had not happened for 2.5 years. After the course of therapy, allergies began to appear much less frequently.”

Marina:

“After a holiday at sea, red spots began to appear in the groin area. They were itching a lot, and their number increased every day. The specialist recommended Triderm. At first I was confused by the price, but the pharmacist assured me that the product was effective. Indeed, the skin calmed down quickly, all manifestations disappeared in 5 days. There were no side effects. I bought cream.”